KMID : 0363320130340040412
|
|
Journal of Korean Oriental Internal Medicine 2013 Volume.34 No. 4 p.412 ~ p.427
|
|
A Comparative Study of Eejin-tang, Hyangsaeejin-tang and Naeso-san Extracts on Indomethacin-induced Gastric Mucosal Lesions in Mice
|
|
Park Jung-Han
Baek Tae-Hyun
|
|
Abstract
|
|
|
Objectives : This study was carried out to compare the effects of Eejin-tang, Hyangsaeejin-tang and Naeso-san extracts on indomethacin-induced gastric mucosal lesions in mice.
Methods : Experimental mice were divided into six groups. The normal group had no gastro-inflammation. In the control
group, gastro-inflammation was elicited by indomethacin. Misoprostol, Eejin-tang, Hyangsaeejin-tang and Naeso-san group were those in which misoprostol, Eejin-tang extract, Hyangsaeejin-tang extract and Naeso-san extract were administered after gastro-inflammation is elicited. This study examined the anti-inflammation effects and distribution of mucus secreting cells, zonula occludin-1 (ZO-1), heat shock protein (HSP) 70, periodic acid-schiff reaction stain (PAS), peanut agglutinin (PNA), cyclooxygenase-1 (COX-1), 5-bromo-2¡®-deoxyuridine (BrdU), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-¥êB) p65, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).
Results : 1. The hemorrhagic erosion and damaged mucus secreting cell, the positive reaction HSP70 increased in the control group, but decreased in the Eejin-tang, Hyangsaeejin-tang and Naeso-san groups. 2. The positive reaction of ZO-1, PAS, PNA, COX-1 and BrdU decreased in the control group, but increased in the Eejin-tang, Hyangsaeejin-tang and Naeso-san groups. 3. The positive reaction of NF-kB p65, iNOS and COX-2 increased in the control group, but decreased in the Eejin-tang, Hyangsaeejin-tang and Naeso-san groups.
Conclusions : Among the three extracts, the effects were in the order of Naeso-san, Hyangsaeejin-tang and Eejin-tang group, Naeso-san being the most effective.
|
|
KEYWORD
|
|
Eejin-tang (Erchen-tang), Hyangsaeejin-tang (Xiangshaerchen-tang), Naeso-san (Neixaio-san), indomethacin, gastric mucosal lesions
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|